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1903
- Indiana University School of Medicine is founded
1921
- The Riley Memorial Association, now the Riley Children's Foundations, is founded with the goal of building a children's hospital in memory of Hoosier Poet James Whitcomb Riley
1924
- Riley Hospital for Children opens
1935
- President Franklin Delano Roosevelt attends the dedication of the hydrotheraputic pool for children with polio
1950
- The Riley Research Building opens as an addition to the Riley Hospital for Children campus
1951
- Indiana's first pediatric cardiac catheterization laboratory opens at Riley
1956
- Indiana's first pediatric open heart procedure is performed at Riley
1962
- Riley becomes the first hospital in the nation to perform percutaneous cardiac catheterization (a minimally invasive diagnostic and treatment procedure) in children
1966
- Riley Hospital for Children becomes the first hospital in Indiana, and one of the first in the nation, to utilize echocardiography to diagnose congenital heart defects
1971
- Indiana's first and only pediatric burn center opens at Riley
- Indiana's first neonatal intensive care unit opens at Riley
- The Parent Care Unit opens at Riley Hospital for Children with open visitation, participation and in-room sleeping accommodations for parents, creating a national model for family-centered care
1975
- The first staged Fontan procedure in Indiana is performed at Riley. The surgery keeps oxygenated blood and deoxygenated blood from mixing in the heart
1980
- Riley becomes the first hospital in Indiana to provide outpatient surgical care for children
1983
- Indiana's first pediatric cochlear implant procedure (to correct deafness) is performed at Riley
1986
- Indiana's first ECMO procedure (a form of heart-lung bypass for critically ill infants and children) is performed at Riley
1988
- Indiana's first pediatric liver transplant is performed at Riley
1989
- Indiana's first infant and newborn heart transplants are performed at Riley
1991
- The Herman B Wells Center for Pediatric Research opens at Riley Hospital for Children
1994
- Indiana's first and only pediatric cancer center, including the state's only stem cell transplant unit, opens at Riley
- Indiana's first pediatric cord blood transplant is performed at Riley
1997
- Riley Hospital for Children joins Indiana University Hospital and Methodist Hospital to form Clarian Health Partners
1997-2006
- Clarian Health Partners is listed among the nation's best hospitals by US News and World Report magazine for nine consecutive years
2000
- The Riley Outpatient Center opens as the nation's largest ambulatory care center for children
2001
- The Riley Sleep Disorders Center opens as the largest pediatric sleep lab in the world
2002
- Indiana's only dedicated unit for children with heart defects, the Riley Heart Center, opens
- Riley is one of just 19 hospitals in the country selected to perform Phase I pediatric cancer research protocols
- One of the nation's three largest autism centers, the Christian Sarkine Autism Treatment Center, opens at Riley
2003
- First intestinal and multi-organ transplants in Indiana performed at Riley
- First hospital in the Eastern United States and only one of two in the U.S. to receive special government permission to use and implant the Berlin Heart, a ventricular assist device. The Berlin Heart is a new way to treat complex cardiac problems
- First time Riley surgeons use Repiphysis, a prosthetic implanted in an arm or leg
- First hospital in Indiana to perform a pulmonary autograft mitral valve replacement, a revolutionary procedure to replace the mitral valve
2004
- Family as Faculty program, part of the Family-Centered Care Program, launched at Riley Hospital for Children
- Riley formalizes partnership with Deaconess Hospital in Evansville
- Riley celebrates 80th birthday
- Riley ranked as one of America's best children's hospitals according to Child Magazine
- Riley Launches Riley Connections - A Telemedicine Program, allowing Riley physicians to consult with out-of-town physicians and patients
2005
- Riley announces its $500 million, 10-year plan
- Riley Hospital for Children at Clarian North Medical Center opens
- Phase V patient tower work begins
- Riley NICU is recognized as among the best five in the nation, according to Child magazine
2006
- Child magazine ranked Riley Hospital 11th in the nation overall out of nearly 250 children's hospitals. The magazine also ranked the hospital's neonatal and pulmonary departments in the top 10.
- The Riley Children's Foundation receives a $10 million gift from the Eli Lilly and Company Foundation to establish a world-class pediatric diabetes treatment and research program
- Riley is the first hospital in Indiana, and among a few hospitals in the nation, to use the Vertical Expandable Prosthetic Titanium Rib
- Riley's ECMO program ranked in the top five internationally
2007
- The Simon Family announces a gift of $40 million toward the completion of the new 10-story, 675,000-square foot inpatient tower
- Riley places fourth among the nation's freeŽstanding children's hospitals with total research funding of $51 million, including $26.2 million from the National Institutes of Health
- Riley earns Level I Trauma verification making it one of 12 children's hospitals in the nation with this designation
- Clarian acquires the Midwest Proton Radiotherapy Institute, one of five in the country and the only one in the Midwest, providing precision treatment for cancer and benign tumors in children and adults
2008
- U.S.News & World Report's 2008 edition of America's Best Children's Hospitals ranked five specialty programs at Riley among the top 30 children's hospitals in the nation
- Riley, Indiana University School of Medicine and Moi University School of Medicine completes construction on the new Riley Mother and Baby Hospital in Eldoret, Kenya
- Riley clinical and translational research a major component of the $25 million NIH Clinical and Translational Science Award to Indiana University School of Medicine
- Riley formalizes longtime relationship with the Capital Institute of Pediatrics of Beijing, China by becoming international sister hospitals
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